Endocrine Abstracts

Introduction: Cushing`s Syndrome (CS) is associated with endothelial dysfunction and premature atherosclerosis, which occurs due to hypercortisolism itself and associated comorbidities including diabetes and hypertension. Advanced glycation end products (AGE) are heterogeneous compounds produced endogenously from the non-enzymatic glycation of proteins, lipids, and nucleic acids, leading to the activation of various stress-induced transcription factors through the stimul...

Introduction: Acromegalic osteopathy is an emerging complication characterized by high risk for vertebral fractures (VFS), whereas bone mineral density (BMD) may not be useful to predict the risk. Recent studies have reported that increased advenced glycation end products (AGEs) are associated with bone fragility. We aimed to evaluate the relationship between AGEs and VFs in patients with acromegaly.Study design: Cross-sectionalPat...

Introduction: Various rates were reported regarding diabetes remission and improvement in hyperglycemia in many studies from different populations. Determinants of diabetes remission have not been definitively established so far. In this study, we aimed to evaluate the long-term glycemic status after bariatric surgery in diabetic obese patients followed by Marmara University Endocrinology Outpatient Clinic.Method: The retrospective study included 233 typ...

The frequency of adrenal masses is increasing in parallel with the progress of the technology. Most of these masses, which are detected by chance, are not functional, and only a part of them are exposed to an excess of hormone. The most common dysfunction in masses with hormonal activity is hypercortisolism. However, the diagnosis of Cushing’s disease is based on more than one test. In this study, we intended to compare the values of screening tests to determine whether t...

Introduction: Pachydermoperiostosis (PDP) is a rare hereditary syndrome with familial and idiopathic forms that is characterized by subperiosteal new bone formation with pain, polyarthritis, cutis vertices grata, seborrhea, hyperhidrosis and digital clubbing. Periostosis and cutaneous thickening along with the absence of any signs of cardiovascular, pulmonary, hepatic, intestinal and mediastinal diseases causing secondary hypertrophic osteoarthropathy suggest PDP. The incidenc...

Introduction: In a recent study, it was determined that morbidity rates due to cardiovascular diseases were affected as a result of long-term follow-up in patients with nonfunctional pituitary adenoma. And cardio/cerebro vascular diseases were the most frequent cause of mortality when mortality rates were examined. In the literature, there are not enough studies evaluating this condition in patients with nonfunctional pituitary adenoma without traditional cardiovascular risk f...

Prevalence of Paget’s disease (PD) of bone as well as clinical and demographical presentation may differ between the populations.Aim: In this study we evaluate clinical and demographical parameters of Paget’s disease patients followed from endocrinology clinics in Turkey.Method: An invitation was sent to all tertiary endocrinology clinics to complete a survey on demographic clinical, laboratory parameters, treatment modal...

Aim: The most common clinical presentation of primary hyperparathyroidism (PHPT) is asymptomatıc and it is diagnosed incidentally without developing complications.In our study, we aimed to examine the characteristics of participants with primary hyperparathyroidism and the relationship between bone mineral density (BMD) and hypercalciuria.Methods: Consecutive 191 normocalciuric (24-h urinary calcium<400 mg/day) patients with PHPT (51±13 yea...

Aim: Clinical presentation of primary hyperparathyroidism (PHPT) differs between populations. In this study, we aimed to examine bone mineral density (BMD) and bone metabolism parameters in newly diagnosed and untreated PHPT patients in a single endocrine center in İstanbul, Turkey.Methods: Consecutive 256 PHPT patients (50.7±14 years, F/M:205/51) and 89 healthy controls (38.8±10 years, F/M:67/22) were included in the study. Serum calcium...

Objective: Radioiodine (RAI), surgical and anti-thyroid drug therapy are the main options to treat Graves’ disease (GD). The aim of this study was to investigate theurapeutic options, their efficacy and adverse reactions of prophilthiouracil (PTU) and methimazole (MMI).Design: A total of 650 patients with GD were evaluated retrospectively. Treatments, adverse reactions, clinical and laboratory results were recorded. After 18 months of primary medica...